Grilled Chicken Spinach Panini

Featured in: Fast Everyday Meals

This Italian-American panini combines tender grilled chicken breasts seasoned with Italian herbs, layered with fresh baby spinach, creamy mozzarella and Parmesan cheese, all bound together with aromatic garlic butter. The sandwich is pressed until the bread turns golden and the cheese melts into every crevice, creating a warm, satisfying meal.

Perfect for lunch or dinner, this 30-minute main dish serves four and pairs beautifully with a fresh green salad or tomato soup. Feel free to customize with turkey, roasted red peppers, or sliced tomatoes for your preferred flavor profile.

Updated on Sun, 18 Jan 2026 10:57:00 GMT
Close-up of a golden-brown Grilled Chicken Spinach Panini cut in half, revealing layers of juicy grilled chicken, fresh spinach, and melted mozzarella cheese on crusty bread. Save
Close-up of a golden-brown Grilled Chicken Spinach Panini cut in half, revealing layers of juicy grilled chicken, fresh spinach, and melted mozzarella cheese on crusty bread. | quickharcha.com

There was a week last winter when I couldn't stop making these paninis. My daughter had started asking for "the pressed cheese sandwich with the green stuff," and suddenly it became our Wednesday ritual. The smell of garlic butter hitting a hot press is impossible to ignore, and the way the cheese oozes out just slightly at the edges makes it worth every bit of cleanup. I've since learned that good bread and a little patience are all you really need to turn grilled chicken into something special.

I made a double batch of these the day my sister came over unannounced, still in her scrubs from a long shift. She sat at the counter while I pressed the sandwiches, and we barely spoke until she finished hers and reached for another half. Sometimes the best compliment is just silence and a second helping. That day taught me that this panini works as comfort food, quick fuel, or something to share when words aren't necessary.

Ingredients

  • Boneless, skinless chicken breasts: Slice them thin after grilling so every bite has tender chicken instead of thick, dry chunks.
  • Olive oil: Brushing the chicken before grilling keeps it juicy and adds a subtle richness that plain seasoning can't achieve.
  • Salt, black pepper, and dried Italian herbs: This trio is my go-to for chicken because it never competes with the garlic butter or cheese.
  • Unsalted butter: Softened butter spreads easily and lets you control the salt level, especially when Parmesan is already salty.
  • Garlic cloves: Fresh garlic makes all the difference; the jarred kind just doesn't have the same sharpness or aroma.
  • Fresh parsley: A handful of parsley brightens the butter and makes it taste less heavy, even though it's still gloriously rich.
  • Rustic Italian or sourdough bread: Sturdy bread holds up to pressing and doesn't turn into mush when the cheese melts.
  • Fresh baby spinach: Make sure it's dry or the panini will steam instead of crisp, and nobody wants a soggy sandwich.
  • Shredded mozzarella cheese: Mozzarella melts into those beautiful cheese pulls, and provolone works just as well if that's what you have.
  • Grated Parmesan cheese: It adds a sharp, nutty layer that keeps the panini from tasting one-note.

Instructions

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Ideal for slow-simmered sauces, braised vegetables, baked dips, and cozy one-pot meals with even heat.
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Fire Up the Grill:
Preheat your grill pan or outdoor grill to medium-high heat so it's ready to sear the chicken with those lovely char marks. A hot surface is key to locking in moisture.
Season and Grill the Chicken:
Brush the chicken breasts with olive oil, season both sides with salt, pepper, and Italian herbs, then grill for 5 to 6 minutes per side until fully cooked. Let them rest for 5 minutes before slicing thinly so the juices stay inside instead of running all over your cutting board.
Mix the Garlic Butter:
In a small bowl, combine softened butter, minced garlic, and chopped parsley until everything is evenly mixed. This is the secret weapon that makes the bread taste like it came from an Italian cafe.
Butter the Bread:
Lay out all your bread slices and spread the garlic butter on one side of each. The buttered side will face outward when you assemble the sandwiches.
Build the Panini:
On the unbuttered side of four slices, layer sliced chicken, a handful of spinach, mozzarella, and a sprinkle of Parmesan, then top with the remaining bread slices with the buttered side facing out. Press down gently so everything holds together.
Press and Cook:
Heat your panini press or a large skillet over medium heat, then cook the sandwiches for 3 to 5 minutes per side until the bread is golden and the cheese is fully melted. If using a skillet, press down with a heavy pan to get that compressed, crispy texture.
Slice and Serve:
Cut each panini in half and serve immediately while the cheese is still gooey. The first bite is always the best when it's this hot.
Product image
Ideal for slow-simmered sauces, braised vegetables, baked dips, and cozy one-pot meals with even heat.
Check price on Amazon
Freshly made Grilled Chicken Spinach Panini served warm beside a small salad, with garlic butter oozing from the toasted Italian bread slices. Save
Freshly made Grilled Chicken Spinach Panini served warm beside a small salad, with garlic butter oozing from the toasted Italian bread slices. | quickharcha.com

One Saturday morning, I packed two of these paninis in foil and took them to the park for a picnic with my nephew. We sat on a blanket, and he declared it "way better than the cafeteria stuff" between bites, which is high praise from a ten-year-old. That day I realized this recipe isn't just about feeding people; it's about creating a moment worth repeating. Food always tastes better when it's shared outside the kitchen.

Choosing Your Bread

I've tried this panini with everything from ciabatta to whole wheat, and the truth is that texture matters more than type. You want bread that's sturdy enough to hold all the fillings without falling apart under pressure, and something with a bit of chew so it doesn't turn into a cracker. Sourdough has that perfect balance of tang and structure, while rustic Italian bread gives you a thicker, softer bite. Avoid soft sandwich bread unless you like the idea of a flat, mushy disaster.

Making It Your Own

This panini is a blank canvas, and I've learned not to be precious about the ingredients. Sometimes I use leftover rotisserie chicken instead of grilling fresh breasts, and it works beautifully as long as the chicken is still moist. Sliced tomatoes or roasted red peppers add a sweet, juicy layer that pairs well with the garlic butter, and I've even swapped mozzarella for fontina when I wanted something a little creamier. The key is to keep the ratios balanced so no single ingredient overpowers the rest.

What to Serve Alongside

A panini this rich doesn't need much competition on the plate, but a simple arugula salad with lemon vinaigrette cuts through the richness and adds a peppery bite. Tomato soup is the obvious pairing, especially if you're leaning into cozy comfort food vibes, and it's perfect for dipping. If you want something lighter, a handful of crispy potato chips or pickles on the side keeps things casual without adding more work to your day.

  • Serve with a crisp green salad dressed in olive oil and lemon to balance the buttery bread.
  • Tomato soup makes this feel like the ultimate comfort meal and is perfect for dipping.
  • A handful of kettle chips or tangy pickles on the side keeps it simple and satisfying.
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Boil water quickly for tea, coffee, instant soups, and faster prep when cooking grains or noodles.
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A steaming Grilled Chicken Spinach Panini pressed to perfection, featuring melted Parmesan and mozzarella cheeses blending with savory grilled chicken and vibrant green spinach. Save
A steaming Grilled Chicken Spinach Panini pressed to perfection, featuring melted Parmesan and mozzarella cheeses blending with savory grilled chicken and vibrant green spinach. | quickharcha.com

This panini has become one of those recipes I don't really think about anymore; my hands just know what to do. I hope it becomes that kind of easy favorite for you too, the kind you make on a random Tuesday without looking at a recipe.

Recipe FAQs

Can I use a regular skillet instead of a panini press?

Yes, absolutely. Place your assembled sandwich in a heated skillet over medium heat, then use a heavy pan or cast iron skillet on top to weigh it down. Cook 3-5 minutes per side until golden brown.

How do I know when the chicken is cooked through?

Grill chicken breasts for 5-6 minutes per side until they reach an internal temperature of 165°F (74°C) when measured with a meat thermometer. The juices should run clear when pierced.

What's the best way to prevent the bread from getting soggy?

Make sure to spread the garlic butter on the outside of the bread before assembling, and dry your spinach thoroughly after washing. This prevents excess moisture from soaking into the bread.

Can I make the garlic butter ahead of time?

Yes, prepare the garlic butter up to 24 hours in advance and refrigerate in an airtight container. Let it soften to room temperature before spreading on the bread for easier application.

What type of bread works best for this panini?

Sturdy, crusty breads like Italian, sourdough, or focaccia work best. Avoid soft breads that will squish under the press. Thicker slices hold up better to pressing and grilling.

Can I substitute the cheese types?

Certainly. Provolone, fontina, or even Swiss cheese are excellent alternatives to mozzarella. For Parmesan substitutes, try aged Pecorino Romano or Asiago for similar sharpness and texture.

Grilled Chicken Spinach Panini

Warm, savory panini with grilled chicken, fresh spinach, melty mozzarella, and garlic butter on crusty Italian bread.

Prep time
15 minutes
Cook time
15 minutes
Total duration
30 minutes
Created by Jack Whitestone


Skill level Easy

Cuisine Italian-American

Makes 4 Portions

Diet-friendly details None specified

What You'll Need

Chicken

01 2 boneless, skinless chicken breasts
02 1 tablespoon olive oil
03 1/2 teaspoon salt
04 1/2 teaspoon black pepper
05 1/2 teaspoon dried Italian herbs

Garlic Butter

01 3 tablespoons unsalted butter, softened
02 2 cloves garlic, minced
03 1 tablespoon fresh parsley, finely chopped

Panini Assembly

01 8 slices rustic Italian or sourdough bread
02 2 cups fresh baby spinach, washed and dried
03 1.5 cups shredded mozzarella cheese
04 0.5 cup grated Parmesan cheese
05 Olive oil for brushing

How to Make It

Step 01

Preheat Cooking Surface: Preheat grill pan or outdoor grill to medium-high heat.

Step 02

Grill Chicken Breasts: Brush chicken breasts with olive oil and season with salt, pepper, and dried Italian herbs. Grill for 5-6 minutes per side until cooked through. Allow to rest for 5 minutes, then slice thinly.

Step 03

Prepare Garlic Butter Spread: Combine softened butter, minced garlic, and finely chopped parsley in a small bowl, mixing until well incorporated.

Step 04

Assemble Bread Foundation: Lay bread slices on work surface and spread garlic butter on one side of each slice.

Step 05

Layer Sandwich Fillings: On the unbuttered side of 4 bread slices, layer sliced grilled chicken, fresh spinach, mozzarella cheese, and Parmesan cheese in sequence. Top each with remaining bread slices, buttered side facing outward.

Step 06

Press and Toast Panini: Heat panini press or large skillet to medium heat. Place sandwiches in press or skillet with a heavy pan as weight. Cook 3-5 minutes per side until bread achieves golden color and cheese melts completely.

Step 07

Finish and Serve: Remove panini from heat, slice diagonally in half, and serve immediately while warm.

Gear you'll need

  • Grill pan or outdoor grill
  • Panini press or large skillet
  • Mixing bowl
  • Knife and cutting board

Allergy notes

Review every ingredient for allergen risks and talk to your doctor if uncertain.
  • Contains wheat from bread
  • Contains milk from cheese and butter
  • May contain gluten traces - verify bread label for sensitivity concerns
  • May contain dairy traces - verify cheese label for sensitivity concerns

Nutrition info (per serving)

All nutrition info here is just for your reference and isn’t a substitute for health advice.
  • Calorie count: 450
  • Fat content: 20 g
  • Carbohydrates: 35 g
  • Proteins: 32 g